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You are here:Home » Antibodies » Antibodies-Enzymes, Myeloperoxidase » Anti -Myeloperoxidase (MPO, pANCA)

Anti -Myeloperoxidase (MPO, pANCA)


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Clone Host Grade Applications
Polyclonal Human Serum E IF
In normal tissues and in a variety of myeloproliferative disorders, myeloid cells of both neutrophilic and eosinophilic types, at all stages of maturation, exhibit strong cytoplasmic reactivity for MPO. It is readily detected in myeloblasts and immature myeloid cells of acute myelogenous leukemia, progranulocytic leukemia, monomyelocytic leukemia, erythro-leukemia, myeloblastomas, and other hematopoietic disorders. Erythroid precursors, megakaryocytes, lymphoid cells, mast cells, and plasma cells are nonreactive.
Catalog #M9760
ApplicationsSuitable for use in ELISA and Immunofluorescence. Other applications not tested.
Recommended DilutionsImmunofluorescence: Exhibits a P-ANCA pattern
Optimal dilution determined by the researcher.
Autoantibody ActivityInterpretation of Results: <16EU/ml: Negative
16-20EU/ml: Equivocal
>20EU/ml: Positive
Anti-MPO Activity by ELISA As reported (lot-specific). Current lot value: 96EU/ml
Interpretation of Results: <4EU/ml: Negative
4.1-5.9EU/ml: Equivocal
>6EU/ml: Positive
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
ConcentrationNot Determined
FormSupplied as a powder lyophilized from a solution containing PBS, 0.02% sodium azide. Reconstitute with 2ml sterile ddH2O.
PurityFractionated from delipidated, defibrinated and precipitated human serum.
ImmunogenMyeloperoxidase (MPO). Autoantibody derived from donor human serum.
SpecificityRecognizes human Myeloperoxidase (MPO, pANCA)
Species CrossreactivityShould detect MPO from most species. Does not recognize PR-3, SS-A, SS-B, Sm, Sm/RNP, SCL and Jo-1 antigens at a 1:1000 dilution in ELISA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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