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You are here:Home » Antibodies » Abs to Enzymes, Myeloperoxidase » Anti -Myeloperoxidase (MPO, pANCA, 84kD Myeloperoxidase, 89kD Myeloperoxidase, Myeloperoxidase Heavy Chain, Myeloperoxidase Light Chain)

Anti -Myeloperoxidase (MPO, pANCA, 84kD Myeloperoxidase, 89kD Myeloperoxidase,
Myeloperoxidase Heavy Chain, Myeloperoxidase Light Chain)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59-64kD) and two unglycosylated beta chains (MW 14kD) with total MW 150kD and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.
Catalog #M9760-10H
Cellular Localization Lysosomal
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No8L864
HostMouse
SourceHuman
Concentration~2mg/ml
FormPBS, pH 7.4 containing 0.1% sodium azide
PurityPurified by Protein A affinity chromatography.
ImmunogenFull length native protein (purified) (Human).
SpecificitySpecies Crossreactivity: Crossreacts with Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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