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You are here:Home » Antibodies » Abs to Enzymes, Myeloperoxidase » Anti -Myeloperoxidase (MPO, pANCA, 84kD Myeloperoxidase, 89kD Myeloperoxidase, Myeloperoxidase Heavy Chain, Myeloperoxidase Light Chain)

Anti -Myeloperoxidase (MPO, pANCA, 84kD Myeloperoxidase, 89kD Myeloperoxidase,
Myeloperoxidase Heavy Chain, Myeloperoxidase Light Chain)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. MPO is an important marker for myeloid cells, from the promyelocyte stage and to the mature forms. CATALYTIC ACTIVITY: Donor + H2O2 = oxidized donor + 2 H2O. CATALYTIC ACTIVITY: Cl- + H2O2 = HOCl + 2 H2O. COFACTOR: Binds 1 calcium ion per heterodimer. COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer. SUBUNIT: Tetramer of two light chains and two heavy chains.
Catalog #M9760-10K
Cellular LocalizationLysosome.
Alternative Products3 named isoforms produced by alternative splicing. DISEASE: Defects in MPO are the cause of myeloperoxidase deficiency (MPD). MPD is an autosomal recessive defect that results in disseminated candidiasis. Belongs to the peroxidase family. XPO subfamily.
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormReconstitute in 250 ul of sterile water. Centrifuge to remove any insoluble material.
PurityPurified by affinity chromatography.
ImmunogenMyeloperoxidase isolated from human polymorphonuclear leucocytes.
SpecificityThis antiserum reacts with human myeloperoxidase. Species Crossreactivity: Human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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