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You are here:Home » Antibodies » Antibodies-Enzymes, Myeloperoxidase » Anti -Myeloperoxidase (MPO, pANCA)

Anti -Myeloperoxidase (MPO, pANCA)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
In normal tissues and in a variety of myeloproliferative disorders, myeloid cells of both neutrophilic and eosinophilic types, at all stages of maturation, exhibit strong cytoplasmic reactivity for MPO. It is readily detected in myeloblasts and immature myeloid cells of acute myelogenous leukemia, progranulocytic leukemia, monomyelocytic leukemia, erythro-leukemia, myeloblastomas and other hematopoietic disorders. Erythroid precursors, megakaryocytes, lymphoid cells, mast cells and plasma cells are nonreactive. Cells of monocytic derivation reveal variable reactivity and are typically weakly positive or nonreactive. Cells comprising the infiltrate of a spectrum of lymphoid malignancies, e.g., lymphoblastic lymphoma or leukemia, chronic lymphocytic leukemia, hairy cell leukemia, non-Hodgkin’s lymphomas of T-or B-cell type and Hodgkin’s disease, are nonreactive, as are the non-neoplastic tissues present in these specimens, except for occasional cells of myeloid derivation. MPO is not observed in the neoplastic cells of a wide variety of epithelial tumors and sarcomas, or in the contiguous non-neoplastic tissues. MPO is useful in differentiating between myeloid and lymphoid leukemias.
Catalog #M9760-12
ApplicationsSuitable for use in ELISA. Other applications have not been tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Recommended PairM9760-10, M9760-13 and M9760-14: Suitable for use as the capture or solid phase antibody.
M9760-12: Suitable for use as the detection or conjugate
(label) antibody.
Hybridoma:
Hybridization of Sp 2/0 myeloma with spleen cells from Balb/c mice.
Source: Ascites
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No1.BB.83
HostMouse
SourceHuman
Concentration~3mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide,.
PurityPurified by Protein A affinity chromotography. Purity is tested by electrophoresis.
ImmunogenHuman myeloperoxidase purified leukocyte mass
SpecificityReacts with human Myeloperoxidase.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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