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You are here:Home » Antibodies » Abs to Enzymes, Myeloperoxidase » Anti -Myeloperoxidase (MPO) (Biotin)

Anti -Myeloperoxidase (MPO) (Biotin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IH FC IF
MPO is a glycoprotein with an alpha2beta2 heteromultimer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegeners disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has more attracted clinical attention.
Catalog #M9760-20A
ApplicationsSuitable for use in ELISA, Flow Cytometry, Immunohistochemistry and Immunofluorescence. Not recommended for Western Blot. Other applications have not been tested.
Recommended Dilutions
Immunohistochemistry (Frozen): 1:50 detects polymorphonuclear neutrophils. Paraffin sections are not recommended.
Flow Cytometry: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2D4
HostMouse
SourceRat
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide. Labeled with Biotin.
PurityPurified by Protein G affinity chromatography.
SpecificityRecognizes rat Myeloperoxidase. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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