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You are here:Home » Antibodies » Abs to Myosin » Anti -Myosin VIIa (Myosin 7a, Myo7a, MYOVIIA, Deafness Autosomal Dominant 11, DFNA11, Deafness Autosomal Recessive 2, DFNB2, MYU7A, NSRD2, Usher Syndrome 1B, Ush1B)

Anti -Myosin VIIa (Myosin 7a, Myo7a, MYOVIIA, Deafness Autosomal Dominant 11, DFNA11,
Deafness Autosomal Recessive 2, DFNB2, MYU7A, NSRD2, Usher Syndrome 1B, Ush1B)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Myosin VIIa is a member of the myosin superfamily of actin-based motor proteins. Defects in the myosin VIIa gene are responsible for hearing impairment in shaker-1 (sh1) mice and causes Usher syndrome IB in humans. Usher syndrome associates congenital deafness, vestibular dysfunction, and retinitis pigmentosa and is the most common form of combined deafness and blindness. Structural features of myosin VIIa protein include an ATP binding N-terminal motor domain, a central region which possess five light-chain binding (IQ) motifs, and a C-terminal domain with three myosin tail homology (MyTH4) and talin-like homology regions.
Catalog #M9848-03H
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 5ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control
Mouse testes tissue extract
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa16-31, S(16)GQEFDVPIGAVVKLC(31) from mouse myosin VIIa.
Species Sequence HomologyHuman and porcine 100%
SpecificityRecognizes Myosin VIIa from mouse tissues as well as the recombinant protein. Detects recombinant mouse myosin VIIa overexpessed in Sf9 insect cell lysate.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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