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You are here:Home » Antibodies » Abs to Myosin » Anti -Myosin IIA, Non-muscle, CT (Myosin-9, Myosin Heavy Chain 9, Myosin Heavy Chain, Non-Muscle IIa, Non-Muscle Myosin Heavy Chain IIa, NMMHC II-a, NMMHC-IIA, Cellular Myosin Heavy Chain, Type A, Non-Muscle Myosin Heavy Chain A, NMMHC-A, Myh9)

Anti -Myosin IIA, Non-muscle, CT (Myosin-9, Myosin Heavy Chain 9, Myosin Heavy Chain,
Non-Muscle IIa, Non-Muscle Myosin Heavy Chain IIa, NMMHC II-a, NMMHC-IIA, Cellular Myosin
Heavy Chain, Type A, Non-Muscle Myosin Heavy Chain A, NMMHC-A, Myh9)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Nonmuscle myosin class II proteins belong to the superfamily of actin-based motor proteins. They form hexamer structures composed of two ~200kD heavy chains (NMHC II) and two pairs of 20kD and 17kD light chains (MLC20 and MLC17). Nonmuscle myosins are classified according to the heavy chain isoforms; light chains are conserved. Three different isoforms that share 64-80% aa sequence identity have been detected in mammals: NMHC II-A, NMHC II-B, and NMHC II-C. Although NMHC II molecules have now been found in muscle cells as well, the name "nonmuscle myosin" was already widespread and is in use today. NMHC II-A is most abundant compared to other NMHC isoforms in human lung, spleen, thymus, uterus, and colon. Thus, single aa mutation in MNMH II-A results in kidney and platelet defects in humans. In addition, recent study indicates that replacement of NMHC II-B with NMHC II-A rescues brain defect in mice.
Catalog #M9848-12B
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the C-terminus of human NMHC II-A.
SpecificityRecognizes human NMHC II-A.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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