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Anti -MYH14, CT (Myosin-14, Myosin heavy chain 14, Myosin heavy chain, non-muscle IIc, Non-muscle myosin heavy chain IIc, NMHC II-C, KIAA2034, FP17425)
Anti -MYH14, CT (Myosin-14, Myosin heavy chain 14, Myosin heavy chain, non-muscle IIc,
Non-muscle myosin heavy chain IIc, NMHC II-C, KIAA2034, FP17425)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Nonmuscle myosin class II proteins belong to the superfamily of actin-based motor proteins. They form hexamer structures composed of two ~200kD heavy chains (NMHC II) and two pairs of 20kD and 17kD light chains (MLC20 and MLC17). Nonmuscle myosins are classified according to the heavy chain isoforms; light chains are conserved. Three different isoforms that share 64-80% aa sequence identity have been detected in mammals: NMHC II-A, NMHC II-B, and NMHC II-C. Although NMHC II molecules have now been found in muscle cells as well, the name "nonmuscle myosin" was already widespread and is in use today. NMHC II-C is most abundant in skeletal muscle, liver, kidney, and specific parts of brain (pons and corpus callosum) compared to other NMHC isoforms. Recently two isoforms of NMHC II-C were reported, differing by inclusion/exclusion of 8aa in their loop 1. Point mutations in NMHC II- C such as R726S affect the inner ear. | | | Catalog # | M9850-17Y | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-2ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the C-terminus of human NMHC II-C. | | Specificity | Recognizes human NMHC II-C. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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