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You are here:Home » Molecular Biology » Growth Factors-GDF » Myostatin Fusion Protein, Recombinant, Human, Propeptide (Growth Differentiation Factor 8, MSTN, gdf8)

Myostatin Fusion Protein, Recombinant, Human, Propeptide (Growth Differentiation Factor 8,
MSTN, gdf8)

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Specifications

Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.
Catalog #M9875-01C
Description 28kD protein containing 243 amino acid residues of the human Myostatin Propeptide and 5 additional amino acid residues. MG NENSEQKE NVEKEGLCNA CTWRQNTKSS RIEAIKIQIL SKLRLETAPN ISKDVIRQLL PKAPPLRELI DQYDVQRDDS SDGSLEDDDY HATTETIITM PTESDFLMQV DGKPKCCFFK FSSKIQYNKV VKAQLWIYLR PVETPTTVFV QILRLIKPMK DGTRYTGIRS LKLDMNPGTG IWQSIDVKTV LQNWLKQPES NLGIEIKALD ENGHDLAVTF PGPGEDGLNP FLEVKVTDTP KRSRRKLN
SpecificityThe amino acid sequence of the recombinant human Myostatin Propeptide is 100% homologous to the amino acid sequence of the human Myostatin Propeptide without signal sequence.
ApplicationsWestern blotting, ELISA
SolubilityAdd 0.2 ml of d H2O and let the lyophilized pellet dissolve completely.
StabilityStore lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20°C.
Molecular Weight28kD
SourceE. coli
Purity95% (SDS-PAGE); Two-step procedure using size exclusion chromatography before and after refolding.
Concentration~1mg/ml
FormSupplied as a lyophilized powder in 20mM Tris, 20mM sodium chloride, pH 8.0.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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