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You are here:Home » Antibodies » Abs to Inflammasomes » Anti -NALP3 (NACHT, LRR and PYD Domains-containing Protein 3, Angiotensin/Vasopressin Receptor AII/AVP-like, Caterpiller Protein 1.1, CLR1.1, Cold Autoinflammatory Syndrome 1 Protein, Cryopyrin, PYRIN-containing APAF1-like Protein 1, NLRP3, C1orf7, CIAS1, PYPAF

Anti -NALP3 (NACHT, LRR and PYD Domains-containing Protein 3, Angiotensin/Vasopressin
Receptor AII/AVP-like, Caterpiller Protein 1.1, CLR1.1, Cold Autoinflammatory Syndrome 1
Protein, Cryopyrin, PYRIN-containing APAF1-like Protein 1, NLRP3, C1orf7, CIAS1, PYPAF

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IC
NALP3 also known as CIAS1, PYPAF or Cryopyrin is a cytosolic ~120kD member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NALP3 activates caspases 1 and 5. Defects in NALP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes. Human NALP3 contains an N-terminal Pyrin domain aa1-93 followed by a Nacht region aa220-536, and seven LRRs aa740-991. Within the sequence used as an immunogen, human NALP3 shares 76% and 75% aa identity with mouse and rat NALP3, respectively. Isoforms of 979, 979, 922 and 719aa lack aa720776, aa836-892, both regions, or terminate at aa719.
Catalog #N0018-64P
ApplicationsSuitable for use in Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunocytochemistry: 8-25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No12K139
HostMouse
SourceHuman
Concentration~0.5mg/ml after reconstitution
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa4-223 from human NALP3 expressed in E.coli.
SpecificityRecognizes human NALP3. Does not react with recombinant human NALP1, 2, 5, rhNALP3 aa540-689, or recombinant mouse NALP3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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