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You are here:Home » Antibodies » Abs to Inflammasomes » Anti -NALP4 (NACHT-, LRR-and PYD-containing Protein 4, NACHT Leucine Rich Repeat and PYD Containing 4, CLR19.5, FLJ32126, Nucleotide Binding Oligomerization Domain Leucine Rich Repeat and Pyrin Domain Containing 4, NLR Family Pyrin Domain Containing 4, NLRP4, P

Anti -NALP4 (NACHT-, LRR-and PYD-containing Protein 4, NACHT Leucine Rich Repeat and PYD
Containing 4, CLR19.5, FLJ32126, Nucleotide Binding Oligomerization Domain Leucine Rich
Repeat and Pyrin Domain Containing 4, NLR Family Pyrin Domain Containing 4, NLRP4, P

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
NALP4 is a 994aa cytoplasmic regulatory protein involved in inflammatory response. It belongs to the NLRP family and contains a PYD domain, eight LRR (leucine rich) repeats and a NACHT domain. Like other NALP proteins, NALP4 may also form multiprotein complexes called inflammasomes and thus may be involved in the activation of proinflammatory caspases and apoptosis. NALP4 is known to resemble Cryopyrin, a protein involved in hereditary hyperinflammation syndromes. Immunoblot and mutation analysis suggest that NALP4 inhibits the induction of NF-kB DNA-binding activity by the cytokine TNF and IL-1B through its PYD domain and also suppress IKKA activity via a mechanism that did not involve its PYD or LRR domain. It is widely expressed in most tissues including spleen, followed by placenta, lung, liver, kidney, pancreas, and thymus.
Catalog #N0018-65A
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum.
ImmunogenSynthetic peptide corresponding to aa606-624 QNVFKKEDEHSSTSDYSL of human NALP4.
SpecificityRecognizes human NALP4. Species Crossreactivity: chimpanzee, rhesus monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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