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You are here:Home » Antibodies » Abs to Inflammasomes » Anti -NALP6 (NACHT, LRR and PYD Domains-containing Protein 6, PYRIN-containing APAF1-like Protein 5, NLRP6, PYPAF5)

Anti -NALP6 (NACHT, LRR and PYD Domains-containing Protein 6, PYRIN-containing APAF1-like
Protein 5, NLRP6, PYPAF5)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
NALP6 is a short NALP functioning in immune cells to coordinate the transduction of pro-inflammatory signals to the activation of NF-kappaB and pro-caspase-1. An 892aa containing cytoplasmic protein, NALP6 belongs to the NLRP family with aDPIN domain, five LRR (leucine-rich) repeats and a NACHT domain. NALPs form a subfamily within the larger CATERPILLER protein family. NALP6 is mainly helpful in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes and promote activation of NF-KB. Highly expressed in granulocytes, but lower levels of NALP6 is detected in T-cells.
Catalog #N0018-67
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa166-183 of human NALP6 GPAEEPEPGRARRSDTHT.
SpecificityRecognizes human NALP6. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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