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You are here:Home » Antibodies » Abs to Inflammasomes » Anti -NALP11 (NACHT, LRR and PYD Domains-containing Protein 11, Nucleotide-binding Oligomerization Domain Protein 17, PAAD-and NACHT Domain-containing Protein 10, PYRIN-containing APAF1-like Protein 6, NLRP11, NOD17, PAN10, PYPAF6)

Anti -NALP11 (NACHT, LRR and PYD Domains-containing Protein 11, Nucleotide-binding
Oligomerization Domain Protein 17, PAAD-and NACHT Domain-containing Protein 10,
PYRIN-containing APAF1-like Protein 6, NLRP11, NOD17, PAN10, PYPAF6)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
NALP11 is a 1033aa containing cytoplasmic protein belonging to the NLRP family with aDPIN domain, six LRR (leucine-rich) repeats and a NACHT domain. Reports suggest that it is a short NALP involved in inflammation potential. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes. TheDPIN domain is necessary and sufficient for suppression of NF-kappa B activation induced by TNF and for inducing IL-1B secretion in collaboration with Caspase-1. It is involved in interaction with PYCARD.
Catalog #N0018-70M
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa467-483 of human NALP11 PNYLIPSGSREYKEKRE.
SpecificityRecognizes human NALP11. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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