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You are here:Home » Antibodies » Abs to Inflammasomes » Anti -NALP12 (NACHT LRR and PYD Containing Protein 12, CLR19.3, Monarch 1, Monarch-1, NLR Family Pyrin Domain Containing 12, NLRP12, PAN6, PYRIN Containing APAF1-like Protein 7, PYPAF7, Regulated by Nitric Oxide, RNO, RNO2)

Anti -NALP12 (NACHT LRR and PYD Containing Protein 12, CLR19.3, Monarch 1, Monarch-1, NLR
Family Pyrin Domain Containing 12, NLRP12, PAN6, PYRIN Containing APAF1-like Protein 7,
PYPAF7, Regulated by Nitric Oxide, RNO, RNO2)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP IH
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes. NALP12 may mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
Catalog #N0018-71
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:2000
Immunohistochemistry: 1:50-1:200. Frozen
Immunohistochemistry: 1:1000-1:2000. Paraffin
Immunoprecipitation: 1:50-1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityWhole antisera
ImmunogenA synthetic peptide corresponding to amino acids 190-208 ([BLAST]QASPIKIETLFEPDEERPE[/BLAST]) of human NALP12/PYPAF7/Monarch-1 was used as immunogen; GenBank no. gi|28436378|gb|AAO18163.1|.
SpecificityRecognizes human NALP12 (NACHT LRR and PYD Containing Protein 12).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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