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You are here:Home » Antibodies » Abs to Inflammasomes » Anti -NALP12 (NACHT LRR and PYD Domains-containing Protein 12, CLR19.3, FCAS2, Monarch 1, Monarch-1, NLR Family Pyrin Domain Containing 12, NLRP12, PAN6, PYRIN Containing APAF1-like Protein 7, PYPAF7, Regulated by Nitric Oxide, RNO, RNO2) (AP)

Anti -NALP12 (NACHT LRR and PYD Domains-containing Protein 12, CLR19.3, FCAS2, Monarch 1,
Monarch-1, NLR Family Pyrin Domain Containing 12, NLRP12, PAN6, PYRIN Containing
APAF1-like Protein 7, PYPAF7, Regulated by Nitric Oxide, RNO, RNO2) (AP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
Catalog #N0018-71A-AP
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note Applications are based on unconjugated antibody.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Alkaline Phosphatase.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide selected from the C-terminal region of human NLRP12 (KLH).
SpecificityRecognizes human NLRP12. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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