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Specifications

Clone Host Grade Applications Polyclonal Sheep Purified E

Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. It is marketed in generic form as its hydrochloride salt, naltrexone hydrochloride, and marketed under the trade names Revia and Depade. Naltrexone and its active metabolite 6-beta-naltrexol are competitive antagonists at Mu- and kappa-opioid receptors, and to a lesser extent at delta-opioid receptors.[1] The plasma half-life of naltrexone is about 4 h, for 6-beta-naltrexol 13 h. The blockade of opioid receptors is the basis behind its action in the management of opioid dependence—it reversibly blocks or attenuates the effects of opioids. Its use in alcohol (ethanol) dependence has been studied and has been shown to be effective. Naltrexone is metabolized mainly to 6 beta-naltrexol by the liver enzyme dihydrodiol dehydrogenase. Other metabolites include 2-hydroxy-3-methoxy-6 beta-naltrexol and 2-hydroxy-3-methoxy-naltrexone. These are then further metabolized by conjugation with glucuronide.
Catalog #	N0018-76
Applications	Suitable for use in ELISA. Other applications not tested.
Recommended Dilution	ELISA: 1.25ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Sheep
Concentration	~1mg/ml
Form	Supplied as a liquid in 20mM phosphate, 150mM sodium chloride, pH 7.2, 0.09% sodium azide.
Purity	Purified
Immunogen	Flunixin (BTG)
Specificity	Recognizes naltrexone.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.