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You are here:Home » Antibodies » Abs to Drugs » Anti -Naltrexone

Anti -Naltrexone

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Purified E
Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. It is marketed in generic form as its hydrochloride salt, naltrexone hydrochloride, and marketed under the trade names Revia and Depade. Naltrexone and its active metabolite 6-beta-naltrexol are competitive antagonists at Mu- and kappa-opioid receptors, and to a lesser extent at delta-opioid receptors.[1] The plasma half-life of naltrexone is about 4 h, for 6-beta-naltrexol 13 h. The blockade of opioid receptors is the basis behind its action in the management of opioid dependence—it reversibly blocks or attenuates the effects of opioids. Its use in alcohol (ethanol) dependence has been studied and has been shown to be effective. Naltrexone is metabolized mainly to 6 beta-naltrexol by the liver enzyme dihydrodiol dehydrogenase. Other metabolites include 2-hydroxy-3-methoxy-6 beta-naltrexol and 2-hydroxy-3-methoxy-naltrexone. These are then further metabolized by conjugation with glucuronide.
Catalog #N0018-76
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1.25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostSheep
Concentration~1mg/ml
FormSupplied as a liquid in 20mM phosphate, 150mM sodium chloride, pH 7.2, 0.09% sodium azide.
PurityPurified
ImmunogenFlunixin (BTG)
SpecificityRecognizes naltrexone.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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