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Anti -Natural Resistance Associated Macrophage Protein (Nramp2)
Anti -Natural Resistance Associated Macrophage Protein (Nramp2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E B |
|
| Natural resistance to infection with unrelated intracellular parasite such as Mycobacteria, Salmonella, and Leishmania is controlled by a single gene that encodes a macrophage-specific membrane protein designated as Natural Resistance-Associated Macrophage Protein (Nramp1). Recently a second member of NRAMP family, termed NRAMP2/DMT/DCT1 (Divalent Metal ion Transporter 1 or Divalent Cation Transporter 1), has been identified (human, rat and mouse 568 aa, ~65% identity with NRAMP1). Unlike NRAMP1, NRAMP2 expression is more ubiquitous and has been detected in most tissues. It is dramatically up-regulated by iron starvation in the intestine. | | | Catalog # | N0020-01B | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-1:5000 ECL. | | ELISA: 1:10,000-50,000 Control peptide can be used to coat ELISA plates at 1ug/ml. | | Optimal dilutions to be determined by the researcher. | | Control Peptide | N0020-02A Natural Resistance Associated Macrophage Protein, Rat, Control Peptide | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Rat | | Concentration | Not determined. | | Form | Supplied as a liquid, PBS, 40% glycerol. | | Purity | Serum. | | Immunogen | A 19 AA Peptide sequence located at the predicted cytoplasmic loop # 4 of rat NRAMP2 (1) (KLH) | | Specificity | Recognizes rat NRAMP2. Species cross-reactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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