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You are here:Home » Antibodies » Abs to Wnt Proteins » Anti -NKD2 (Protein Naked Cuticle Homolog 2, Naked-2, hNkd2)

Anti -NKD2 (Protein Naked Cuticle Homolog 2, Naked-2, hNkd2)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
Naked1 (Nkd1) and Naked2 (Nkd2) are homologs of Drosophila Naked cuticle, a negative regulator of Wnt/Wingless signaling pathway which functions through a feedback mechanism. Both Drosophila and vertebrate Naked proteins contain a putative calcium-binding EF-hand motif; however, Drosophila Naked binds to zinc instead of calcium. Naked inhibits the canonical Wnt/B-catenin pathway by binding to Dishevelled proteins and directs Dishevelled activity towards the planar cell polarity pathway. Naked1 is a direct target of Wnt signaling and is overexpressed in some colon tumors due to constitutive activation of Wnt/B-catenin pathway. Naked2 is myristoylated and is required for sorting of TGF-alpha to the basolateral plasma membrane of polarized epithelial cells.
Catalog #N0021-05A
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-HKRYRQKGREGHS, from NKD2, at the internal region of the protein (NP_149111.1).
SpecificityRecognizes NKD2. Species sequence homology: Human, mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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