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You are here:Home » Antibodies » Abs to Peptides » Anti -Brain Natriuretic Peptide (BNP)

Anti -Brain Natriuretic Peptide (BNP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E IH RIA
Brain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. BNP belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a common 17 aa ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic peptides (eleven of the 17 aa residues are homologous in the ring of each of the natriuretic peptides). BNP is a 32 aa peptide with disulfide bond between the cysteine residues Cys10 and Cys26. In earlier studies it has been demonstrated that BNP concentration in blood increases with the severity of congestive heart failure. Quantitative measurement of BNP in blood provides an objective indicator of congestive heart failure severity.
Catalog #N0520-25A
ApplicationsSuitable for use in RIA, ELISA, and Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder. No preservative added. Reconstitute with 0.1ml PBS, 10mg/ml BSA.
PuritySerum
ImmunogenSynthetic peptide corresponding to human Brain Natriuretic Polypeptide covalently attached to bovine thyroglobulin.
SpecificityRecognizes human Brain Natriuretic Peptide (BNP). Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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