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You are here:Home » Antibodies » Abs to Ion Transport » Anti -NBC3 (HCO3 Cotransporters 3)

Anti -NBC3 (HCO3 Cotransporters 3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
Bicarbonate, along with CO2, is the major pH buffer of biological fluids. The inter-conversion of CO2 to HCO3- is mediated by family of carbonic anhydrases. Several organs specialize in the mobilization of HCO3-. The pancreatic ducts move CO2 and HCO3- from the blood into pancreatic secretions. The kidneys reabsorb massive amount of HCO3- daily (amount of NaHCO3 contained in 1 Ib of baking soda) through the glomerular flirtation of ~180 liters of plasma. To prevent a massive acidosis, thebe tissue specific. Physiologically, NBC is electrogenic, Na+ and HCO3- dependent, Cl- independent, and inhibited by stilbenes (DIDS and SITS). The NBC family of proteins are 30-35% related to anion exchangers (AE2 and AE3; SLC4A1-SLC4A3) and display the same protein topology: (a) At least 10 TM domains with both the N and C-termini predicted to be intracellular, (b) presence of a large, glycosylated, extracellular loop between TM5 and TM6; and (c) the lysine residues are conserved at predicted DIDS-reactive sites.
Catalog #N0538-06
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:10,000-1:100,000. Using 50-100ng of control peptide/well.
Optimal dilutions to be determined by the researcher.
Control PeptideN0538-10: NBC3, Human (HCO3 Cotransporters 3)
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
PuritySerum
ImmunogenA 19-aa peptide sequence within the C-terminus, cytoplasmic domain of human NBC3.
SpecificityRecognizes human NBC3 (HCO3 Cotransporters 3). Species sequence homology: chimp,100%,; rat, 83%; Xenopus, 68%.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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