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Anti -NEIL1 (Endonuclease 8-like 1, DNA Glycosylase/AP Lyase Neil1, DNA-(Apurinic or Apyrimidinic Site) Lyase Neil1, Endonuclease VIII-like 1, FPG1, Nei Homolog 1, NEH1, Nei-like Protein 1)
Anti -NEIL1 (Endonuclease 8-like 1, DNA Glycosylase/AP Lyase Neil1, DNA-(Apurinic or
Apyrimidinic Site) Lyase Neil1, Endonuclease VIII-like 1, FPG1, Nei Homolog 1, NEH1,
Nei-like Protein 1)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E IH |
|
| Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. | | | Catalog # | N0590-08E | | Applications | Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | ELISA: 1:16,000 | | Immunohistochemistry (Paraffin): 5-10ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-DIPSLEPEGTSAS, from human NEIL1, at C-terminal (NP_078884.2). | | Specificity | Recognizes human NEIL1. Species sequence homology: Bovine and porcine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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