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You are here:Home » Antibodies » Abs to Netrin » Anti -Netrin 1 (Netrin 1, Ntn1, NTN1L, Unc6)

Anti -Netrin 1 (Netrin 1, Ntn1, NTN1L, Unc6)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Semaphorins, neuropilins and netrins are among a number of molecules and their receptors that regulate the developing nervous system to guide the development of neural circuits.1 Although first identified as axon guidance cues,2,3 it is now apparent that many of these same factors are not limited to the guidance of growing axons, but have roles in a range of processes from the guidance of cell migration to the regulation of the immune response, angiogenesis, lung branching morphogenesis, nervous system regeneration, and cancer.4-9
The semaphorins make up the largest family of axon guidance cues. They are characterized by the presence of an approximately 500 amino acid N-terminal semaphorin (Sema) domain. Semaphorins function mainly as chemorepellents that direct axons away from tissues.3 Semaphorin 3A (Sema3A) has been shown to be repellent to cortical axons and to inhibit axon branching.10 The transmembrane protein semaphorin 6A has been shown to repel embryonic sympathetic axons.11 The actions of the various semaphorins are not always similar. Semaphorin 3A has been found to inhibit tumor development whereas semaphorin 6A may contribute to tumor progression.9
Catalog #N1193-16B
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.5-1ug/ml
Western Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No9A20
HostMouse
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 5% trehalose.
PurityPurified by Protein G affinity chromatography.
ImmunogenPurified, recombinant protein corresponding to mouse Netrin-1, expressed in NS0 cells
SpecificityRecognizes mouse Netrin 1. Species crossreactivity: recombinant human Netrin-1. Does not crossreact with recombiant human Netrin-2, or- 4, recombinant mouse Netrin-4 or -G1a.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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