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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B IH

Neuroligin-1 is a neuronal cell surface protein belonging to the type-B carboxylesterase/lipase family. It is a necessary component in the maturation of excitatory synapses for their normal, functional development, and is necessary to the regulation of synaptic plasticity and the development of long-term memory within the adult amygdala in mammals. It is believed to participate in cell-cell-interaction through the assembly of intracellular junction by the binding of beta-neurexins, and may also be a factor in the maintenance and assembly of synaptic junctions. It is also thought to have involvement in excitatory synaptic specification. Within brain tissue, Neuroligin-1 is primarily observed in neurons and spinal cord.
Catalog #	N1260-01B
Applications	Suitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
	Western Blot: 0.5ug/ml detects Neuroligin-1 on 10ug of rat brain membrane tissue lysate.
	Immunohistochemistry (paraffin): 1:300 detects Neuroligin-1 in rat adult brain tissue.
	Optimal dilutions to be determined by the researcher.
Positive Control	Rat brain membrane tissue lysate
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1k
Clone No	11C248
Host	Mouse
Source	Rat
Concentration	~1mg/ml
Form	Supplied as a liquid in Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Purity	Purified by Protein G affinity chromatography.
Immunogen	Recombinant protein corresponding to rat Neuroligin-1.
Specificity	Recognizes rat Neuroligin-1.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.