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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B IH

Neuroligins are Type I membrane proteins enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. They have been characterized as neuronal cell surface proteins and are thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. They play a major role in the formation or maintenance of synaptic junctions. They are also thought to be involved in the specification of excitatory synapses. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses.
Catalog #	N1260-03C
Applications	Suitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
	Western Blot: 1ug/ml detects Neuroligin-3 on 10ug of rat brain membrane tissue lysate.
	Immunohistochemistry (paraffin): 1:400 detects Neuroligin-3 in rat brain (putamen area) and rat cerebellum tissue.
	Optimal dilutions to be determined by the researcher.
Positive Control	Rat brain membrane tissue lysate
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1k
Clone No	11C249
Host	Mouse
Source	Rat
Concentration	~0.5mg/ml
Form	Supplied as a liquid in Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Purity	Purified by Protein G affinity chromatography.
Immunogen	Recombinant protein corresponding to rat Neuroligin-3 at the cytoplasmic domain.
Specificity	Recognizes rat Neuroligin-3.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.