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Abs to Neuroligins
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Anti -NEUROLIGIN 3 (NLGN3, ASPGX1, AUTSX1, Gliotactin Homolog, HNL3, KIAA1480, Neuroligin-3, NL3)
Anti -NEUROLIGIN 3 (NLGN3, ASPGX1, AUTSX1, Gliotactin Homolog, HNL3, KIAA1480,
Neuroligin-3, NL3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B |
|
| NLGN3 is a 110-114kD member of the type-B carboxyesterase/lipase family of proteins. It is a neuronal transmembrane protein that forms Ca++-dependent intercellular junctions with short b-neurexin isoforms. This seems to contribute to both glutamatergic and GABAergic synapse formation. Mutations in NLGN3 are associated with a reduction in protein expression and the occurrence of autism. Mature human NLGN3 is an 811aa type I transmembrane protein. It contains a 672aa extracellular domain (ECD) aa38-709, plus a 118aa cytoplasmic region. The ECD possesses a nonfunctional carboxyesterase domain aa41-625 Multiple splice variants exist. There is a deletion of aa153-172 that may also be accompanied by an alternative start site at Met118, and a deletion of aa153-192 that may also be accompanied by a five Lys substitution for aa554-848. Over aa39-709, human NLGN3 shares 99aa identity with mouse NLGN3. | | | Catalog # | N1260-03D1 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 2ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2B | | Clone No | 11n136 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml. | | Purity | Purified by Protein A/G affinity chromatography. | | Immunogen | Recombinant corresponding to aa38-709 from human Neuroligin 3/NLGN3 expressed in NSO cells (NP_061850). | | Specificity | Recognizes human Neuroligin 3. Species sequence homology: Recombinant human Neuroligin 3v2 and recombinant rat Neuroligin 3v4 (100% ). No cross-reactivity with Neuroligin 2, Neuroligin 4, Neuroligin 1, 1v2, or 2v2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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