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You are here:Home » Antibodies » Abs to Neuroligins » Anti -NEUROLIGIN 3 (NLGN3, ASPGX1, AUTSX1, Gliotactin Homolog, HNL3, KIAA1480, Neuroligin-3, NL3)

Anti -NEUROLIGIN 3 (NLGN3, ASPGX1, AUTSX1, Gliotactin Homolog, HNL3, KIAA1480,
Neuroligin-3, NL3)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
NLGN3 is a 110-114kD member of the type-B carboxyesterase/lipase family of proteins. It is a neuronal transmembrane protein that forms Ca++-dependent intercellular junctions with short b-neurexin isoforms. This seems to contribute to both glutamatergic and GABAergic synapse formation. Mutations in NLGN3 are associated with a reduction in protein expression and the occurrence of autism. Mature human NLGN3 is an 811aa type I transmembrane protein. It contains a 672aa extracellular domain (ECD) aa38-709, plus a 118aa cytoplasmic region. The ECD possesses a nonfunctional carboxyesterase domain aa41-625 Multiple splice variants exist. There is a deletion of aa153-172 that may also be accompanied by an alternative start site at Met118, and a deletion of aa153-192 that may also be accompanied by a five Lys substitution for aa554-848. Over aa39-709, human NLGN3 shares 99aa identity with mouse NLGN3.
Catalog #N1260-03D1
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2B
Clone No11n136
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa38-709 from human Neuroligin 3/NLGN3 expressed in NSO cells (NP_061850).
SpecificityRecognizes human Neuroligin 3. Species sequence homology: Recombinant human Neuroligin 3v2 and recombinant rat Neuroligin 3v4 (100% ). No cross-reactivity with Neuroligin 2, Neuroligin 4, Neuroligin 1, 1v2, or 2v2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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