You are here:Home
»
Antibodies
»
Abs to Receptors, Tyrosine Kinase
»
Anti -NTRK2 (TRKB, BDNF/NT-3 Growth Factors Receptor, GP145-TrkB, Trk-B, Neurotrophic Tyrosine Kinase Receptor Type 2, TrkB Tyrosine Kinase, Tropomyosin-related Kinase B)
Anti -NTRK2 (TRKB, BDNF/NT-3 Growth Factors Receptor, GP145-TrkB, Trk-B, Neurotrophic
Tyrosine Kinase Receptor Type 2, TrkB Tyrosine Kinase, Tropomyosin-related Kinase B)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP IF |
|
| Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145kD, 110kD and the unglycosylated form of 80kD. trkB contains 33.3% carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting through trkB such as BDNF. | | | Catalog # | N2017-36C | | Applications | Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Immunofluorescence: 5-10ug/ml | | Western Blot: 0.5-4ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa810 from human TrkB. | | Specificity | Recognizes human TrkB at ~80kD, ~110kD and ~140kD. Species Crossreactivity: mouse, rat and chicken. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
