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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -NTRK2 (TRKB, BDNF/NT-3 Growth Factors Receptor, GP145-TrkB, Trk-B, Neurotrophic Tyrosine Kinase Receptor Type 2, TrkB Tyrosine Kinase, Tropomyosin-related Kinase B)

Anti -NTRK2 (TRKB, BDNF/NT-3 Growth Factors Receptor, GP145-TrkB, Trk-B, Neurotrophic
Tyrosine Kinase Receptor Type 2, TrkB Tyrosine Kinase, Tropomyosin-related Kinase B)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IF
Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145kD, 110kD and the unglycosylated form of 80kD. trkB contains 33.3% carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting through trkB such as BDNF.
Catalog #N2017-36C
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionImmunofluorescence: 5-10ug/ml
Western Blot: 0.5-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa810 from human TrkB.
SpecificityRecognizes human TrkB at ~80kD, ~110kD and ~140kD. Species Crossreactivity: mouse, rat and chicken.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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