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You are here:Home » Growth Factors, Cytokines » Growth Factors-NGF » Nerve Growth Factor, beta Recombinant, Human (NGFb)

Nerve Growth Factor, beta Recombinant, Human (NGFb)

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Specifications

Human NGF-beta is a neurotrophic factor related to BDNF, NT-3 and NT-4. Human NGF-beta acts as a neurotrophic factor through its receptor beta-NGFR, and is involved in the development and sustaining the sensory and sympathetic nervous systems. H-NGFbeta also is also involved in the growth and differentiation of B lymphocytes and B-cell survival. Human NGF-beta is a noncovalently disulfide-linked homodimer, consisting of 121 amino acids with a molecular weight of two 13.6kD polypeptide monomers.
Catalog #N2050-10C
Endotoxin <0.01ng/ug or <0.1EU/ug as per LAL
AA SequenceMSSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRR
Biological Activity Biological acitivity is determined by the ability to stimulate chick E9 DRG neurite growth. The ED50 is < 1.0ng/ml, corresponding to a specific activity of > 1x10e6 units/mg.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight13.6 kD
SourceRecombinant, human, E. coli
Purity97% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE.
FormSupplied as a lyophilized powder. Reconstitute with sterile dH2O PBS to 0.1-1mg/ml, which can be further diluted into other aqueous solutions.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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