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You are here:Home » Antibodies » Abs to Neurofilament » Anti -Neurofilament M, 160kD (NF-M)

Anti -Neurofilament M, 160kD (NF-M)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant B IH
Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexs of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble.
Catalog #N2160-02G
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionWestern Blot: 1:1000-1:2000
Immunohistochemistry (frozen): 1:50-1:1000 4% PFA fixed tissue sections
Optimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No2Q168
HostMouse
SourceRat
ConcentrationNot determined
FormSupplied as a liquid with no preservatives.
PuritySupernatant
ImmunogenPurified recombinant fusion protein containing the last 168 amino acids of rat NF-M.
SpecificityRecognizes an epitope from the last 84 amino acids of rat NF-M (145K). Reacts specifically with NF-M from a variety of mammalian and avian species.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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