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You are here:Home » Antibodies » Abs to Neurofilament » Anti -Neurofilament M 160kD (NF-M)

Anti -Neurofilament M 160kD (NF-M)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH
Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-L antibody can also be useful in the diagnostics of neurofilament accumulations seen in many neurological diseases, such as Lou Gehrig’s disease or Alzheimerís disease.
Catalog #N2160-02H
Application(s) Immunohistochemistry, Western Blot.
Recommended DilutionWestern Blot 1:5000
Immunohistochemistry 1:1000. Cryostat sections and formalin-fixed paraffin-embedded sections
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as ascites, 0.1% sodium azide.
PuritySerum
ImmunogenRecombinant C-terminal segment of rat NF-M
SpecificityRecognizes the evolutionarily conserved extreme C-terminal region of the medium neurofilament subunit (~145-170kDa). Species crossreactivity: Reacts with NF-M from all mammalian, avian and reptiles tested to date, including human, feline, rat, mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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