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Specifications

Clone Host Grade Applications Polyclonal Rabbit Serum B IH

Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-L antibody can also be useful in the diagnostics of neurofilament accumulations seen in many neurological diseases, such as Lou Gehrig’s disease or Alzheimerís disease.
Catalog #	N2160-02H
Application(s)	Immunohistochemistry, Western Blot.
Recommended Dilution	Western Blot 1:5000
	Immunohistochemistry 1:1000. Cryostat sections and formalin-fixed paraffin-embedded sections
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Rat
Concentration	Not determined
Form	Supplied as ascites, 0.1% sodium azide.
Purity	Serum
Immunogen	Recombinant C-terminal segment of rat NF-M
Specificity	Recognizes the evolutionarily conserved extreme C-terminal region of the medium neurofilament subunit (~145-170kDa). Species crossreactivity: Reacts with NF-M from all mammalian, avian and reptiles tested to date, including human, feline, rat, mouse.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.