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You are here:Home » Antibodies » Abs to Neurofilament » Anti -Neurofilament H, 180-220kD (NF-H) )

Anti -Neurofilament H, 180-220kD (NF-H) )

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified IH
Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells. In the electron microscope neurofilaments appear as 10nm diameter fibres of indeterminate length which generally have fine wispy protrusions from their sides. They are found particularly abundantly in axons of large projection neurons. They probably function to provide structural support for neurons and their synapses and to support the large axon diameters required for rapid conduction of impulses down axons. They are composed a mixture of subunits which usually include the three neurofilament triplet proteins known as NFL, NFM and NFH. Neurofilaments may also include smaller amounts of peripherin, alpha internexin, nestin and in some cases vimentin. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons and are biochemically very stable.
Catalog #N2160-06D
ApplicationsSuitable for use in staining neuronal processes in Immunohistochemistry on frozen and paraffin wax embedded tissue sections. Other applications have not been tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
SourceTissue culture supernatant,
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2Q164
HostMouse
SourceHuman
Concentration~100ug/1ml
FormSupplied as a liquid in PBS, pH 7.2 BSA, sodium azide, and 40% glycerol.
PurityPurified by hydrophobic interaction chromatography.
SpecificityRecognizes the 200kD neurofilament polypeptide in mammalian and avian tissue. Tumors specifically recognized include phaeochromocytoma, paraganglioma, ganglioneuroblastoma and other tumors of neuronal origin.
Species crossreactivityRat, chicken, porcine and reptile.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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