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Abs to Neurofilament
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Anti -Neurofilament H (Neurofilament Heavy Polypeptide, NF-H, Neurofilament Triplet H Protein, 200kD Neurofilament Protein, Nefh, Nfh)
Anti -Neurofilament H (Neurofilament Heavy Polypeptide, NF-H, Neurofilament Triplet H
Protein, 200kD Neurofilament Protein, Nefh, Nfh)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
IH |
|
| Neurofilaments (NFs), the intermediate filaments (IFs) specific to neurons, is the predominant cytoskeletal elements in many nerve cells. They are believed not only to confer mechanical stability, but also to play a role in determining axonal caliber. The human NF-H gene has three introns, two of which interrupt the protein-coding sequence at identical points to introns in the genes for the two smaller NF proteins, NF-M and NF-L having mol. wts predicted from their gene sequences of-110 000,-102 000 and-62 000 respectively. Each type of NFs contains a central a-helical 'rod' domain of-310aa, characterized by a heptad repeat in the aa sequence in which the first and fourth residues are apolar. Perikaryal NFs are predominantly unphosphorylated, while axonal NFs are highly phosphorylated. Defect in NFH causes susceptibility to amyotrophic lateral sclerosis. It has an important function in mature axons. | | | Catalog # | N2160-16D | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 1:25-1:50 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Brain | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E293 | | Host | Mouse | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Supernatant. | | Immunogen | Triton x 100 insoluble rat brain protein. Cellular Localization: Cytoplasmic. | | Specificity | Recognizes rat Neurofilament H. Species Crossreactivity: human. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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