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Specifications

Clone Host Grade Applications Polyclonal Goat Affinity Purified E B IH

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.
Catalog #	N2171-15A
Applications	Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution	ELISA: 1:8000
	Western Blot: 0.1-0.3ug/ml
	Immunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Host	Goat
Source	Human
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide C-KIKSGERGRKG from an internal region of human Neurogranin.
Specificity	Recognizes human NRGN. Species sequence homology: mouse, bovine and canine.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.