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You are here:Home » Antibodies » Abs to Receptors » Anti -Neurokinin B Receptor (NK-3 Receptor)

Anti -Neurokinin B Receptor (NK-3 Receptor)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH IF
The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma. Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).
Catalog #N2171-60
ApplicationsSuitable for use in Immunohistochemistry and Immunofluorescence. Not suitable for use in Western Blot. Other applications not tested.
Recommended DilutionsImmunofluorescence (IC): 1:10-1:2000
Immunohistochemistry (Frozen): 1:10-1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot Determined
FormSupplied as a liquid, 0.1% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to the C-terminus of rat Neurokinin B Receptor (NK-3 Receptor) conjugated to bovine thyroglobulin.
SpecificityRecognizes the rat NK-3 receptor. Specificity was verified by the localization of immunohistochemical staining as well as preabsorption studies with NK-3 peptide. Species Crossreactivity: mouse and guinea pig in brain, spinal cord and ileum. Does not react with human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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