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You are here:Home » Antibodies » Abs to Neuron Specific Enolase » Anti -Neuron Specific Enolase (NSE, 2-phospho-D-glycerate Hydrolyase, Enolase 2, Enolase-2, Eno2, ENOG, Enolase 2 (gamma, neuronal), Gamma Enolase, Neural Enolase, Neuron Specific gamma Enolase)

Anti -Neuron Specific Enolase (NSE, 2-phospho-D-glycerate Hydrolyase, Enolase 2,
Enolase-2, Eno2, ENOG, Enolase 2 (gamma, neuronal), Gamma Enolase, Neural Enolase, Neuron
Specific gamma Enolase)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH
Enolase is a glycolytic enzyme catalyzing the reaction pathway between 2 phospho glycerate and phosphoenol pyruvate. In mammals, enolase molecules are dimers composed of three distinct subunits (alpha, beta and gamma). The alpha subunit is expressed in most tissues and the beta subunit only in muscle. The gamma subunit is expressed primarily in neurons, in normal and in neoplastic neuroendocrine cells. NSE (neuron specific enolase) is found in elevated concentrations in plasma and certain neoplasias. These include pediatric neuroblastoma and small cell lung cancer. Coexpression of NSE and chromogranin A is common in neuroendocrine neoplasms.
Catalog #N2175-02G
Cellular Localization Cytoplasmic
ApplicationsSuitable for use in Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceBovine
ConcentrationNot determined
FormAs reported
PurityWhole antisera
ImmunogenNeuron specific enolase (gamma-gamma isoenzyme) isolated from all bovine brain.
SpecificityThis antibody reacts with human isoenzymes of neuron specific enolase containing gamma subunits. This antibody gives a specific staining in neurons of the brain, in islets of langerhans in pancreas and in peripheral nerves of the skin. No staining with other tissue types has been seen. Species Crossreactivity: Human and bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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