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You are here:Home » Antibodies » Abs to Neuron Specific Enolase » Anti -Neuron Specific Enolase (NSE)

Anti -Neuron Specific Enolase (NSE)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH
Neuron specific enolase (NSE) is the neuronal form of the enolase glycolytic enzymes that catalyze the interconversion of 2-phosphoglycerate and phosphoenolpyruvate. NSE has a molecular weight of 45kD, and is expressed in normal pituitary, pinealocytes, neuroendocrine cells of the lung, thyroid, parafollicular cells, adrenal medulla, Langerhans islet cells, Merkel cells of the skin, melanocytes, normal striated muscle, and hepatocytes. NSE is a useful marker for neuroblastoma, small cell lung carcinoma, and neuroendocrine cancers.
Catalog #N2175-17
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: Frozen and formalin fixed paraffin embedded tissue sections. No pretreatment or epitope retrieval required.
Optimal dilutions to be determined by the researcher.
Positive Control TissuePancreas
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No3G208
HostMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
PurityPurified
ImmunogenBovine brain. Expected Staining Pattern: Cytoplasmic.
SpecificityRecognizes the gamma subunits of human NSE (neuronal origin) and does not react with the alpha subunits (glial origin). Some crossreactivity with the beta subunits of NSE may be observed in muscle. In normal tissues, it has been shown to stain pancreas, brain, colon and stomach.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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