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You are here:Home » Antibodies » Abs to Cathepsin » Anti -Neutrophil Cathepsin G

Anti -Neutrophil Cathepsin G

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E
Cathepsins are a group of intracellular proteolytic enzymes located within the lysosomes. On the basis of the specificity towards their substrates, the cathepsins have been assigned the names: Cathepsins A, B, C, D, E, G H and L. Cathepsin G is a serine protease, it consists of a single polypeptide with a MW of 30kD as determined by SDS-PAGE. Its substrates are collagen and proteoglycans. Cathepsins are localized primarily in lysosomes or endosomes, but translocated to the cytosol during apoptosis. The translocation allows these proteases to interact with caspases or other apoptosis signaling mechanisms. Studies show that cathepsins cleave certain caspases, and caspase inhibitors can inhibit cathepsin activity in vitro.
Catalog #N2257
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No2Q2215
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid. No preservatives added.
PurityAscites.
ImmunogenHuman neutrophils.
SpecificityRecognizes human neutrophil cathespsin G but not the homologous proteases elastase, proteinase 3 or esterase N. Plays an important role in neutrophil biology and disease states.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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