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Neutrophil Cytosolic Factor 4 (NCF4, Neutrophil NADPH Oxidase Factor 4) Recombinant, Human
Neutrophil Cytosolic Factor 4 (NCF4, Neutrophil NADPH Oxidase Factor 4) Recombinant, Human
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| This protein is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. | | | Catalog # | N2258 | | Species | Homo sapiens | | Source | E. coli | | Primary Sequence (aa) | 348 | | Domain (aa) | Full-length | | Tag/Fusion Partner | T7 Tag | | Applications | Suitable for use in ELISA as an Antigen, Ligand, or Assay Standard. Other applications not tested. | | Quality Control | SDS-PAGE Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months. | | Important note | This recombinant enzyme has NOT been tested with regard to biological activity. | | Source | E. coli | | Purity | Highly purified | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2. No preservative added. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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