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Abs to Protein Kinase Inhibitors
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Anti -NFKBIA, phosphorylated (Ser32, 36) (NF-kappa-B Inhibitor alpha, I-kappa-B-alpha, IkappaBalpha, IkB-alpha, Major Histocompatibility Complex Enhancer-binding Protein MAD3, NFKBI, MAD3, IKBA)
Anti -NFKBIA, phosphorylated (Ser32, 36) (NF-kappa-B Inhibitor alpha, I-kappa-B-alpha,
IkappaBalpha, IkB-alpha, Major Histocompatibility Complex Enhancer-binding Protein MAD3,
NFKBI, MAD3, IKBA)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E Gel |
|
| NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime. | | | Catalog # | N2306-60E | | Applications | Suitable for use in ELISA and Dot Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:1,000 | | Dot Blot: 1:500 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in PBS, 0.18% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser32/36 of human NFKBIA (KLH). | | Specificity | Recognizes human NFKBIA when phosphorylated at Ser32 and Ser36. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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