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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -NFKBIA (S32, 36) (NF-kappa-B Inhibitor alpha, I-kappa-B-alpha, IkappaBalpha, IkB-alpha, Major Histocompatibility Complex Enhancer-binding Protein MAD3, NFKBI, MAD3, IKBA)

Anti -NFKBIA (S32, 36) (NF-kappa-B Inhibitor alpha, I-kappa-B-alpha, IkappaBalpha,
IkB-alpha, Major Histocompatibility Complex Enhancer-binding Protein MAD3, NFKBI, MAD3,
IKBA)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Catalog #N2306-60G
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide between aa19-49 of human NFKBIA. (KLH)
SpecificityRecognizes human NFKBIA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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