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You are here:Home » Antibodies » Antibodies-Protein Kinase Inhibitors » Anti -nfkbiab, NT (Nfkbi-alpha-B, Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B Cells Inhibitor, alpha b, Dr.77409)

Anti -nfkbiab, NT (Nfkbi-alpha-B, Nuclear Factor of kappa Light Polypeptide Gene Enhancer
in B Cells Inhibitor, alpha b, Dr.77409)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b (Nfkbi-alpha B, previously called IkB-alpha-B) plays an integral role in vertebrate development. In humans, nuclear factor kappa beta (NFKB) complexes are held in cytoplasm and bound to members of the NFKB inhibitor family (IkB). Studies on other animal models and the inactivation of the NFKB pathway show severe defects in embryonic development and prenatal death. Observation of IkB- alpha-B expression in zebrafish shows a distinct pattern during embryonic development despite ubiquitous expression in embryonic tissues. One study demonstrated high conservation and compatibility of NFKB and IKB proteins across vertebrate species in utilizing murine IkB to interfere with the NFKB pathway in zebrafish embryonic development. The IkB kinase (IKK) activity, which processes IkB proteins, negatively regulates NFKB and can function as a repressor.
Catalog #N2306-64A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Control Peptide N2306-64P
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the N-terminal region of zebrafish Nfkbi-alpha B.
SpecificityRecognizes zebrafish Nfkbi-alpha B.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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