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You are here:Home » Antibodies » Abs to Receptors, Cholinergic » Anti -Nicotinic Acetylcholine Receptor (nAChR)

Anti -Nicotinic Acetylcholine Receptor (nAChR)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites B IP IH
Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine. The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine. The nAChRs fall into two subclasses, the muscle-type and the neuronal-type. The muscle-type receptor is a pentameric glycoprotein of five membrane spanning subunits, (2 alpha 1ís, beta 1, gamma or epsilon and delta) which form a ligand gated ion channel. The neuronal nAChR is also a pentamer, but unlike the muscle-type, is made up of only two general types of subunits, alpha and beta of which multiple subtypes have been described (alpha 2 to alpha 8 and beta 2 to beta 4).
Catalog #N2562-01
Application(s)
Immunohistochemistry (frozen sections (1:1'000))
Immunoprecipitation
Western Blot (1:5000)
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D608
HostMouse
FormLiquid. Ascites diluted in PBS containing 0.05% sodium azide.
PurityAscites
ImmunogenPurified Torpedo californica AChR (acetylcholine receptor).
SpecificityRecognizes the intracellular domain of skeletal muscle nAChR and subunits in Torpedo californica and the subunit in mouse, rat, chicken and frog. Detects bands of ~60kDa ( subunit ) and ~65kDa ( subunit ) by Western blot. Does not cross-react with the 1 and 1 subunits in muscle or the neuronal nAChRs.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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