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You are here:Home » Antibodies » Abs to Receptors, Cholinergic » Anti -Nicotinic Acetylcholine Receptor beta (CHRNB1, Cholinergic receptor, nicotinic, beta (muscle), Acetylcholine receptor subunit beta, ACHRB, CHRNB, CMS1D, CMS2A, FLJ57107, SCCMS) (extracellular)

Anti -Nicotinic Acetylcholine Receptor beta (CHRNB1, Cholinergic receptor, nicotinic, beta
(muscle), Acetylcholine receptor subunit beta, ACHRB, CHRNB, CMS1D, CMS2A, FLJ57107,
SCCMS) (extracellular)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Serum B IC FC
The nicotinic acetylcholine receptor controls electrical signaling between nerve and muscle cells by opening and closing a gated, membrane-spanning pore. The gate is a constricting hydrophobic girdle at the middle of the lipid bi-layer, formed by weak interactions between neighboring inner helices. When acetylcholine enters the ligand-binding domain, it triggers rotations of the protein chains on opposite sides of the entrance to the pore (1). The widespread distribution of the beta subunit suggests it may serve as a common subunit in different AChR combinations in various brain regions. Regulation of the expression of beta subunit appears to be relatively unrestrained, with an apparent excess of protein synthesized in the cytoplasm relative to that which ultimately arrives at functional targets in the plasma membrane (2).
Applications:
Suitable for use in Western Blot, Immunocytochemistry and Flow Cytometry. Other applications not tested.
Catalog #N2562-08C
Recommended DilutionsWestern Blot: 1:1000-1:2000
Immunocytochemistry: 1:100
Flow Cytometry: 1:30
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E404
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
PuritySerum
ImmunogenA synthetic peptide corresponding to residues in the extracellular region of human Acetylcholine receptor subunit beta.
SpecificityRecognizes human nAChR. Species Crossreactivity: mouse and rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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