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You are here:Home » Antibodies » Abs to Receptors, Cholinergic » Anti -Nicotinic Acetylcholine Receptor alpha 1 (nAChR, Acetylcholine Receptor Protein alpha Chain Precursor, ACHRA, ACHRD, Cholinergic Receptor Nicotinic alpha Polypeptide 1, CHRNA1, CHNRA, CMS2A, FCCMS, SCCMS, Schizophrenia Neurophysiologic Defect Candidate)

Anti -Nicotinic Acetylcholine Receptor alpha 1 (nAChR, Acetylcholine Receptor Protein
alpha Chain Precursor, ACHRA, ACHRD, Cholinergic Receptor Nicotinic alpha Polypeptide 1,
CHRNA1, CHNRA, CMS2A, FCCMS, SCCMS, Schizophrenia Neurophysiologic Defect Candidate)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Upon binding of acetylcholine, the acetylcholine receptor responds by undergoing an extensive change of conformation which affects its alpha and beta subunits and leads to the opening of an ion-conducting channel across the plasma membrane. At least 2 isoforms of the alpha-1 subunit are produced from alternate splicing. Isoform 1 is only expressed in skeletal muscle whereas isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.
Catalog #N2562-08D
Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 0.75ug/ml. Band expected at ~55kD.
Immunohistochemistry (FFPE): 1-2ug/ml. Heat mediated antigen retrieval is required.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitute with 100ul sterile ddH20.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa22-36, EHETRLVAKLFKDYS from the N-terminus of human Nicotinic Acetylcholine Receptor alpha 1.
SpecificityRecognizes human Nicotinic Acetylcholine Receptor alpha 1. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAcetylcholine Receptor Subunit alpha, Human mRNA for Muscle Acetylcholine Receptor alpha Subunit


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