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You are here:Home » Antibodies » Abs to Receptors, Cholinergic » Anti -Nicotinic Acetylcholine Receptor alpha 1 (nAChR, Acetylcholine Receptor Protein alpha Chain Precursor, ACHRA, ACHRD, Cholinergic Receptor Nicotinic alpha Polypeptide 1, CHRNA1, CHNRA, CMS2A, FCCMS, SCCMS, Schizophrenia Neurophysiologic Defect Candidate)

Anti -Nicotinic Acetylcholine Receptor alpha 1 (nAChR, Acetylcholine Receptor Protein
alpha Chain Precursor, ACHRA, ACHRD, Cholinergic Receptor Nicotinic alpha Polypeptide 1,
CHRNA1, CHNRA, CMS2A, FCCMS, SCCMS, Schizophrenia Neurophysiologic Defect Candidate)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
The acetylcholine receptor of muscle, like the nicotinic acetylcholine receptor of the Torpedo electric organ, has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma, and delta subunits. The alpha subunit exists in 2 isoforms. The protein-coding sequence of the human ACHRA gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule. Human nicotinic acetylcholine receptor genes alpha is assigned to chromosome 2. Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity.
Catalog #N2562-08E
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
Immunohistochemistry (paraffin):1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH20. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with sterile dH2O.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to a sequence at the N-terminal of acetylcholine receptor alpha1, identical to the related mouse and rat sequences.
SpecificityRecognizes human nAChR. Species Cross-Reactivity: mouse, rat, rabbit.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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