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Nigericin Sodium


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Nigericin sodium is not a typical salt. Since nigericin is an ionophore its very high affinity for monovalent cations such as Na+ and K+ means formation ofa salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid are readily extracted into organic solvents. The sodium ion is stabilized within a polar pocket of the structure effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.
Catalog #N2566-90A
Apperance White powder
Solubility Soluble in DMSO, partially soluble in methanol and methanol, poor water solubility
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number28643-80-3
Molecular FormulaC40H67NaO11
Molecular Weight746.9
SourceStreptomyces hygroscopicus
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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