Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Biochemicals » Biochem-Molecular Biology » Nimbolide (4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723, NSC-309909)

Nimbolide
(4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-se
cochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723,
NSC-309909)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Catalog #N2567-38
A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax.
SolubilityDMSO (50mM)
Molecular Weight~466.52
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number25990-37-8
Molecular FormulaC H O
Molecular Weight~466.52
Purity~98% (TLC)
ConcentrationNot determined
FormSupplied as a white to off-white solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links