Nimbolide
(4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-se
cochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723,
NSC-309909)
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| Catalog # | N2567-38 | | A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms | reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax. | | Solubility | DMSO (50mM) | | Molecular Weight | ~466.52 | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | 25990-37-8 | | Molecular Formula | C H O | | Molecular Weight | ~466.52 | | Purity | ~98% (TLC) | | Concentration | Not determined | | Form | Supplied as a white to off-white solid. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Nimbolide (4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723, NSC-309909) |
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