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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -NIPP1 (Nuclear Inhibitor of Protein Phosphatase 1, Activator of RNA Decay, ARD1, PPP1R8, Protein Phosphatase 1 Regulatory Subunit 8)

Anti -NIPP1 (Nuclear Inhibitor of Protein Phosphatase 1, Activator of RNA Decay, ARD1,
PPP1R8, Protein Phosphatase 1 Regulatory Subunit 8)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.
Catalog #N2568
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml. Detects a band of ~40kD (predicted molecular weight: 40kD) in human lung and H460 cell extracts.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified from goat serum by ammonium sulfate precipitation followed by immunoaffinity chromatography.
ImmunogenSynthetic peptide: EAWPGKKPTPSLLI (Human).
SpecificityRecognizes human NIPP1. Expected to crossreact with Mouse (100% identity with immunogen) due to sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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