Anti -Nkx 2.5 (NKX2.5, NKX2-5, Homeobox Protein Nkx-2.5, Cardiac-specific Homeobox, CSX,
CSX1, CHNG5, Homeobox Protein CSX, Homeobox Protein NK-2 Homolog E, NKX2E, NKX4-1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
B |
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| NKX2.5 is a member of the NKX homeobox transcription factor family. NKX2.5 plays an essential role in heart development and is among the earliest factors expressed in cardiac lineage of developing embryos. Its targeted disruption in mice causes abnormal heart morphogenesis, severe growth retardation, and embryonic lethality around E9.5. Defects in NKX2.5 is associated with several forms of congenital heart diseases, such as atrial defect with atrioventricular conduction defects (ASD-AVCD) and tetralogy of Fallot (TOF). Transcription activation of NKX2.5 is also associated with certain B and T cell leukemias resultant from chromosomal translocation. | | | Catalog # | N2850-18E | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.3-1ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human Heart lysates | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-PRAYSDPDPAKDPR, from the internal region of the protein sequence (NP_004378.1; NP_001159647.1; NP_001159648.1). | | Specificity | Recognizes human NKX2-5. Species sequence homology: mouse, rat, canine, bovine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Nkx 2.5 (NKX2.5, NKX2-5, Homeobox Protein Nkx-2.5, Cardiac-specific Homeobox, CSX, CSX1, CHNG5, Homeobox Protein CSX, Homeobox Protein NK-2 Homolog E, NKX2E, NKX4-1) |
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