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You are here:Home » Antibodies » Abs to Transcription Factors, Homeobox (HOX) » Anti -Nkx 2.5 (NKX2.5, NKX2-5, Homeobox Protein Nkx-2.5, Cardiac-specific Homeobox, CSX, CSX1, CHNG5, Homeobox Protein CSX, Homeobox Protein NK-2 Homolog E, NKX2E, NKX4-1)

Anti -Nkx 2.5 (NKX2.5, NKX2-5, Homeobox Protein Nkx-2.5, Cardiac-specific Homeobox, CSX,
CSX1, CHNG5, Homeobox Protein CSX, Homeobox Protein NK-2 Homolog E, NKX2E, NKX4-1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
NKX2.5 is a member of the NKX homeobox transcription factor family. NKX2.5 plays an essential role in heart development and is among the earliest factors expressed in cardiac lineage of developing embryos. Its targeted disruption in mice causes abnormal heart morphogenesis, severe growth retardation, and embryonic lethality around E9.5. Defects in NKX2.5 is associated with several forms of congenital heart diseases, such as atrial defect with atrioventricular conduction defects (ASD-AVCD) and tetralogy of Fallot (TOF). Transcription activation of NKX2.5 is also associated with certain B and T cell leukemias resultant from chromosomal translocation.
Catalog #N2850-18F
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 0.3-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-PRAYSDPDPAKDPR, from CSX1, at the internal region of the protein (NP_004378.1, NP_001159647.1, NP_001159648.1).
SpecificityRecognizes human CSX1. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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