You are here:Home
»
Antibodies
»
Abs to Transcription Factors, Homeobox (HOX)
»
Anti -NKX3.1 (Homeobox Protein Nkx-3.1, Homeobox Protein NK-3 Homolog A, NKX3-1, NKX3A)
Anti -NKX3.1 (Homeobox Protein Nkx-3.1, Homeobox Protein NK-3 Homolog A, NKX3-1, NKX3A)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| NKX3.1, a 234aa tumor suppressor protein, is a novel member of NK Class of Homeodomain proteins. It is a human homolog of NK3 (Drosophila) and Nkx3.1 (Mouse) and consists of a highly conserved DNA-binding Homeodomain. It plays a vital role in prostrate epithelial cell development, differentiation and carcinogenesis. Its expression is androgen-regulated and has growth suppression and differentiation effects in prostrate epithelial cells. It acts as a transcriptional repressor of PSA promoter by interacting with Prostrate-derived Ets factor. Its role has also been implicated in growth of testicular epithelial cells. It is specifically expressed in prostrate and testis & loss of expression has been detected in prostrate carcinomas, prostatic intraepithelial neoplasia and testicular cancers of germ cell origin. | | | Catalog # | N2850-30N | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Human NKX3.1. | | Specificity | Recognizes human NKX3.1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
